Momordica charantia (KARELA)

Popularly called by researchers as ‘Plant Insulin’. M. charantia has been so named because the fruit contains a polypeptide made of 17 amino acids out of which 16 are similar to crystalline insulin of bovine origin which has also been found to be effective in clinical 3,4 trials in primary diabetes.
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Zingiber officinale (SOUNTH)

Like A. indica, the therapeutic role of Z. officinale in diabetes is bivariant. Its primary action in treating hyperglycemia is mediated through its stimulatory effect on B-cells to secrete insulin.
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PURE Commiphora mukul (GUGGUL)

One of the major complications of untreated or under treated diabetes is elevated levels of very low density lipoproteins (VLDL) in blood circulation. The VLDL is converted in the liver to more cholesterol rich low density lipoproteins that accumulate progressively on the mucosal lining of blood capillaries with subsequent narrowing of the vessel lumina.
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Azadirachta indica (NEEM)

A widely used drug in Ayurveda, gaining ever-growing popularity in modern times. A. indica, the next important ingredient in KARNIM shows its anti-diabetic action by stimulating the insulin secretion by the B-cells of Islet of Langerhans of the pancreas in a manner similar to the sulfonylureas like chlorpropamide.
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Ocimum sanctum (TULSI)

O. sanctum promotes uptake of glucose by peripheral tissue most likely either by decreasing peripheral resistance to insulin or any other action finally resulting in promotion of insulin: receptor interaction.
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Picrorhiza kurroa (KUTKI)

The main action of P. kurroa in treating hyperglycemia is attributed to the bitter principles, kutkin contained in the roots. These bitter principles are known to stimulate secretion of gastrin, secretin & chotecystokinin pancreozymin which then stimulate the secretion of insulin by B-cells of pancreas.
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