Like A. indica, the therapeutic role of Z. officinale in diabetes is bivariant. Its primary action in treating hyperglycemia is mediated through its stimulatory effect on B-cells to secrete insulin. This action has been attributed to 6, 8 & 10 gingerols present in Z. + + 14 officinale. which are assumed to cause inhibition of Na /K pump. Reduced potassium conductance causes membrane depolarisation ++ ++ & influx of Ca ions through voltage sensitive Ca channels which ultimately stimulates insulin secretion by B-cells of pancreas.

In addition to increasing blood insulin levels, Z. officinale has a 15 secondary influence in lowering lipid levels in blood . Elevated fatty acid levels in diabetes is a common feature due to increased lipolysis which is taken care by Z. officinale. Hence, it acts to prevent the onset of atherosclerosis, one of the major complications in diabetes.