0. sanctum promotes uptake of glucose by peripheral tissue most likely either by decreasing peripheral resistance to insulin or any other action finally resulting in promotion of insulin: receptor interaction. This accounts for the finding that it potentiates the 16 action of all medicaments including exogenously injected insulin, 5 M. charantia & A. indica . Stress is known to be a causative factor of diabetes.

Several states of physical stress such as acute myocardial infarction, surgery, infections & severe burns & trauma associated with glucose intolerance induced by hormonal effects on glucose metabolism & 12 insulin secretion & action . Aggravation of hyperglycemia precipitated by stress is effectively taken care by 0. sanctum which is known to possess anti-stress activity. It normalizes the stress induced 17,18 neurohumoral changes.