KARNIM is a combination of proven anti-diabetics fortified with potent Immunomodulators, Antihyperlipidemics, Anti-stress & Hepatoprotectives of total plant origin. The formulation of KARNIM is based on ancient ayurvedic references, further corroborated through modern research & clinical trials at major medical institutes.

KARNIM – A UNIQUE REMEDY

  • KARNIM acts on different sites in different ways to effectively control factors & pathways leading to Diabetes Mellitus. Synthetic anti-diabetics act on one site in only one way.
  • KARNIM is the only drug to correct the cause as well as effects, besides the condition itself. lt attacks the various factors which precipitate the diabetic condition & corrects the degenerative complications which result because of diabetes.
  • KARNIM is safe & effective in managing Diabetes Mellitus as a single agent supplement to synthetic anti-diabetic drugs.
  • KARNIM helps overcome resistance to oral hypoglycemic drugs when used as adjuvant to cases of uncontrolled diabetes.
  • KARNIM confers a sense of well-being in patients & promotes symptomatic relief of complaints like weakness, giddiness, pain in legs, body ache, polyuria & pruritis.

MANAGEMENT OF DIABETES USING KARNIM

KARNIM is a specially formulated capsule containing ingredients that directly or indirectly contribute in controlling diabetes. A combination of herbal drugs (see Table 1) with varying modes of action, KARNIM exerts its anti-diabetic activity in several ways.

TABLE 1 : KARNIM – ITS COMPOSITION

 INGREDIENTS  QUANTITY / CAPSULE
 Momordica charantia (Karela)  150 mg.
 Azadirachta indica (Neem)  75 mg.
 Ocimum sanctum (Tulsi)  75 mg.
 Picrorhiza kurroa (Kutki)  35 mg.
 Zingiber officinale (Sounth)  30 mg.
 Pure Commiphora mukul (Shudha Guggul)  35 mg.

HOW NATURE MAGICALLY ACTS

1

Momordica charantia (KARELA)

Popularly called by researchers as ‘Plant Insulin’. M. charantia has been so named because the fruit contains a polypeptide made of 17 amino acids out of which 16 are similar to crystalline insulin of bovine origin which has also been found to be effective in clinical 3,4 trials in primary diabetes.
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3

Zingiber officinale (SOUNTH)

Like A. indica, the therapeutic role of Z. officinale in diabetes is bivariant. Its primary action in treating hyperglycemia is mediated through its stimulatory effect on B-cells to secrete insulin.
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5

PURE Commiphora mukul (GUGGUL)

One of the major complications of untreated or under treated diabetes is elevated levels of very low density lipoproteins (VLDL) in blood circulation. The VLDL is converted in the liver to more cholesterol rich low density lipoproteins that accumulate progressively on the mucosal lining of blood capillaries with subsequent narrowing of the vessel lumina.
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2

Azadirachta indica (NEEM)

A widely used drug in Ayurveda, gaining ever-growing popularity in modern times. A. indica, the next important ingredient in KARNIM shows its anti-diabetic action by stimulating the insulin secretion by the B-cells of Islet of Langerhans of the pancreas in a manner similar to the sulfonylureas like chlorpropamide.
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4

Ocimum sanctum (TULSI)

O. sanctum promotes uptake of glucose by peripheral tissue most likely either by decreasing peripheral resistance to insulin or any other action finally resulting in promotion of insulin: receptor interaction.
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6

Picrorhiza kurroa (KUTKI)

The main action of P. kurroa in treating hyperglycemia is attributed to the bitter principles, kutkin contained in the roots. These bitter principles are known to stimulate secretion of gastrin, secretin & chotecystokinin pancreozymin which then stimulate the secretion of insulin by B-cells of pancreas.
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THERAPEUTIC EFFECTS AND PROPHYLACTIC ROLE OF KARNIM

COMBINED EFFECTS OF INGREDIENTS OF KARNIM

In a study, M. charantia, A. indica & O. sanctum in combination showed inhibitory effects on enhanced gluconeogenesis from proteins & amino acids with the accurnulation of glycogen in liver. Ultimately, blood glucose level reduced significantly & remained 5 maintained till the termination of the drug. KARNIM, as a complete prescribed formulation produces highly significant reduction in blood glucose level progressively improving up to the end of 31 months (see fig. 1).

KARNIM also reduces different symptoms associated with 31 diabetes (see fig. 2). Addition of KARNIM after one month to the therapy of glibenclamide, caused a further reduction of blood sugar level by 26.7% in fasting blood sugar & by 44.21% in post-prandial blood 31 sugar, during the second month (see fig. 3,4).

Fig. 1: Monthly actual mean values of Blood sugar with KARNIM for 3 months

Fig. 2: Relief in Symptoms with KARNIM

Fig. 3: Increasing response of KARNIM (mean blood sugar reduction in mg % monthwise)

Fig. 4: KARNIM’s potentiation effect of Hypoglycemics of Glibenclamide

Clinical Trials:

  1. R. A. Poddar Medical College (Ayur) & M. A. Poddar Hospital, Worli, Mumbai.
  2. Grant Medical College & Sir J. J. Group of Hospitals, Mumbai.